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There may be limited support for tools like Sims4Studio on Linux, but even a quick google shows how some people got it to work decently.
It would largely depend on what kind of mods you are planning to make. Pure tuning can be done in TDESC Browser and then packaged with S4S, which skips over performance issues the latter may have on an unsupported OS.
Or if you're referring to using mods in general, that part should be fine.
Scribe of tutorials. Oracle of questions at NRaas. Blog staller at thecardinalsims. Feel free to @ me for input on any TS3/TS4 modding questions.